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http://www.lantyng.url.tw/en/custom_119873.html SCI國際期刊- Int J Nanomedicine, 2020:15, 4191-4203. SCI國際期刊- Int J Nanomedicine, 2020:15, 4191-4203. .auto-style1 { font-family: Georgia, "Times New Roman", Times, serif; } .auto-style2 { font-size: x-large; } .auto-style3 { font-family: Georgia, "Times New Roman", Times, serif; font-size: large; } Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male RatsZwe-Ling Kong, Jia-Ling He, Sabri Sudirman, Mao-Tien Kuo, Song Miao, Ke-Liang B Chang, David TsouPMID: 32606672 | PMCID: PMC7305344 | DOI: 10.2147/IJN.S252885 AbstractPurpose: To characterize the nanoparticle of antroquinonol from A. cinnamomea and its ameliorative effects on the reproductive dysfunction in the diabetic male rat.Material and methods: The chitosan-silicate nanoparticle was used as the carrier for the delivery of antroquinonol from solid-state-cultured A. cinnamomea extract (AC). The rats were fed with a high-fat diet and intraperitoneally injected with streptozotocin to induce diabetes. The rats were daily oral gavage by water [Diabetes (DM) and Control groups], three different doses of chitosan-silicate nanoparticle of antroquinonol from solid-state-cultured A. cinnamomea (nano-SAC, NAC): (DM+NAC1x, 4 mg/kg of body weight; DM+NAC2x, 8 mg/kg; and DM+NAC5x, 20 mg/kg), solid-state-cultured AC (DM+AC5x, 20 mg/kg), or metformin (DM+Met, 200 mg/kg) for 7 weeks.Results: The nano-SAC size was 37.68±5.91 nm, the zeta potential was 4.13±0.49 mV, encapsulation efficiency was 79.29±0.77%, and loading capacity was 32.45±0.02%. The nano-SAC can improve diabetes-induced reproductive dysfunction by regulating glucose, insulin, and oxidative enzyme and by increasing the level of testosterone, follicle-stimulating hormone, luteinizing hormone, and sperm count as well as sperm mobility. In testicular histopathology, the seminiferous tubules of A. cinnamomea-supplemented diabetic rats showed similar morphology with the control group.Conclusion: The nanoparticle of antroquinonol from Antrodia cinnamomea can be used as an effective strategy to improve diabetes-induced testicular dysfunction.Keywords: Antrodia cinnamomea; antroquinonol; diabetes; male reproduction; nanoparticles. © 2020 Kong et al.
http://www.lantyng.url.tw/en/custom_70764.html SCI - Molecules. 2017, 22(5), 747. SCI - Molecules. 2017, 22(5), 747. Molecules2017, 22(5), 747In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea MyceliumAbstractTwo new ubiquinones, named antrocinnamone and 4-acetylantrocamol LT3, were isolated along with six known ubiquinones from Antrodia cinnamomea (Polyporaceae) mycelium. The developed HPLC analysis methods successfully identified eight different ubiquinones, two benzenoids, and one maleic acid derivative from A. cinnamomea. The ubiquinones 1–8 exhibited potential and selective cytotoxic activity against three human cancer cell lines, with IC50 values ranging from 0.001 to 35.883 μM. We suggest that the different cytotoxicity levels were related to their chemical structures, especially the 4-hydroxycyclohex-2-enone ring and the presence of a free hydroxyl group in the side chain. The suppression by 4-acetylantrocamol LT3 stopped the cell cycle at the beginning of the G2-M phase thus making the cell cycle arrest at the sub-G1 phase as compared with control cells.Figures
http://www.lantyng.url.tw/en/custom_70765.html SCI - Front. Pharmacol., 21 March 2016 SCI - Front. Pharmacol., 21 March 2016 Frontiers in Pharmacology., 21 March 2016 | https://doi.org/10.3389/fphar.2016.00067Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 CellsAntrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction. During chronic ER stress, misfolded proteins accumulate and initiate β-cell apoptosis. Moreover, β-cell dysfunction leads to defect in insulin secretion, which is the key process in the development and progression of T2DM. Therefore, the aim of the present study was to examine the effects of A. camphorata on insulin secretion and ER stress-induced apoptosis in a mouse β-cell line, MIN6, and their underlying mechanisms. We demonstrated that the ethanolic extract of A. camphorata increased glucose-induced insulin secretion dose-dependently through peroxisome proliferator-activated receptor-γ (PPAR-γ) pathway, and upregulated genes that were involved in insulin secretion, including PPAR-γ, glucose transporter-2 and glucokinase. Furthermore, A. camphorata slightly increased cell proliferation, as well as protected from ER stress-induced apoptosis in MIN6 cells. In conclusion, this study provided evidences that A. camphorata might have anti-diabetic effects and could be a novel drug for T2DM.ResultsAntrodia camphorata Enhanced Glucose-Induced Insulin Secretion through PPAR-γ PathwayFIGURE 1Antrodia camphorata Increased PPAR-γ, GLUT-2, and GLK Expressions in MIN6 CellsFIGURE 2Antrodia camphorata Protected from ER Stress-Induced Apoptosis in MIN6 CellsFIGURE 3FIGURE 4Antrodia camphorata Protected from Apoptosis through Downregulation of IRE1α Pathway in MIN6 CellsFIGURE 5
http://www.lantyng.url.tw/en/custom_70762.html SCI - Fitoterapia. 2015, 102: 115-119. SCI - Fitoterapia. 2015, 102: 115-119. FitoterapiaVolume 102, April 2015, Pages 115-119Anti-cancer agents derived from solid-state fermented Antrodia camphorata myceliumAbstractThree new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata (Polyporaceae) mycelium. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analyses. These ubiquinones exhibited selective cytotoxicities against five human cancer cell lines (CT26, A549, HepG2, PC3 and DU-145) with IC50 values ranging from 0.01 to 1.79 μΜ.Graphical abstractThree new ubiquinone derivatives, antrocamol LT1, LT2 and LT3, were isolated from Antrodia camphorate mycelium and exhibited potential cytotoxicities against five human cancer cell lines.
http://www.lantyng.url.tw/en/custom_67453.html 13 Invention Patents 13 Invention Patents 美國專利3件證書號 US 9,622,990 B2證書號 US 9,474,775 B2證書號 US 9,249,117 B2 台灣專利7件證書號 I510237證書號 I569797證書號 I527583證書號 I543760證書號 I466677證書號 I583376證書號 I626053 大陸專利2件證書號 ZL2013 10204312 .X證書號 ZL2014 10080982 .X 日本專利1件證書號 特願2014-007022
http://www.lantyng.url.tw/en/custom_67452.html What's Antrocamols? What's Antrocamols? 蘭亭生技研發團隊使用特有配方以無菌的固態發酵培養牛樟芝,104年於國際學術期刊Fitoterapia發表與確認牛樟芝新型化合物- Antrocamol,為蘭亭生技專利成分。 且經技術改良後大幅度地提高有效成分的產量,含量可達5%以上。Antrocamols為蘭亭牛樟芝中所發現全新的成分群,非一般多醣體、三萜類,為一全新的小分子結構,將定為蘭亭牛樟芝的「指標性成分、品管成分、保健功效成分」,在牛樟芝研 究領域具有創新與突破性。
http://www.lantyng.url.tw/en/custom_70759.html Patent Technology - Antrocamols Patent Technology - Antrocamols Antrocamol 美國新專利1. 證書號 US 9,622,990 B2 (LT1, LT2)2. 證書號 US 9,474,775 B2 (LT3)3. 證書號 US 9,249,117 B2 (LT1, LT2, LT3)Antrocamol 台灣新專利1. 證書號 I583376 (LT1, LT2)2. 證書號 I466677 (LT3)3. 證書號 I543760 (LT1, LT2)4. 證書號 I569797 (LT1, LT2, LT3)Antrocamol 大陸新專利1. 證書號 ZL201310204312.X (LT1, LT2)Antrocamol 日本新專利1. 證書號 特許第5908002號 (LT1, LT2, LT3)
http://www.lantyng.url.tw/en/custom_70760.html Patent Technology - Antroquinonol B Patent Technology - Antroquinonol B Antroquinonol B, 4-acetyl-Antroquinonol B 台灣新專利1. 證書號 I510237
http://www.lantyng.url.tw/en/custom_70761.html Patent Technology - SY-1 Patent Technology - SY-1 SY-1 台灣新專利1. 證書號 I5275832. 證書號 I626053SY-1 大陸新專利1. 證書號 ZL2014 10080982 .X
http://www.lantyng.url.tw/en/custom_67454.html R&D ACHIEVEMENT R&D ACHIEVEMENT Fitoterapia. 2015, 102: 115-119.  SCI國際期刊KEYWORDS: antrocamol LT1; antrocamol LT2; antrocamol LT3; Antrodia camphorata; Cytotoxicity; Ubiquinone derivativeMolecules. 2017, 22(5), 747.  SCI國際期刊KEYWORDS: Antrodia cinnamom; ubiquinone derivative; antrocinnamone; 4-acetylantrocamol LT3; cytotoxicity; flow cytometry; cell cycle中國實驗方劑學. 2015 (10): 118-122.  雙核心期刊KEYWORDS: Antrodia camphorata; hepatoma; SMMC-7721 cells; cell apoptosisFrontiers in Pharmacology. 2016.  SCI國際期刊KEYWORDS: Antrodia camphorata; PPAR-γ; insulin secretion; pancreatic β-cell death; type 2 diabetes mellitus3th世界中醫藥教育大會.  會議論文KEYWORDS: Antrodia camphorata; PPAR-γ; insulin secretion; pancreatic β-cell death; type 2 diabetes mellitus
http://www.lantyng.url.tw/en/custom_67455.html SBIR - R&D and innovation SBIR - R&D and innovation 經濟部小型企業創新研發計畫(SBIR)「生技製藥 - 創新技術」補助牛樟芝對代謝症候群臨床前有效性及其化合物Antrocamol之作用機轉研究糖尿病是一種常見的慢性綜合代謝疾病,它的主要臨床症狀表現為血糖值過高,並由此引發一系列嚴重的健康問題。目前臨床市場以化學和生物合成的降血糖藥物為主,這些藥物對血糖的治療效果 非常顯著,然而均存在嚴重的副作用或者依賴性。牛樟芝(Antrodia cinnamomea)是一種藥用真菌,僅原生於台灣。本計畫進行蘭亭生技改良後之牛樟芝在糖尿病此一常見慢性綜合代謝疾病的有效性,後續將遵循衛生福利部食品藥物管理署的 規定申請牛樟芝調節血糖健康食品查驗登記許可。
http://www.lantyng.url.tw/en/ Lantyng Biotechnology Co., Ltd.
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