http://www.lantyng.url.tw/cn/custom_70764.htmlSCI国际期刊 - Molecules. 2017, 22(5), 747.SCI国际期刊 - Molecules. 2017, 22(5), 747.Molecules2017, 22(5), 747In Vitro Anticancer Activity and Structural Characterization of Ubiquinones from Antrodia cinnamomea MyceliumAbstractTwo new ubiquinones, named antrocinnamone and 4-acetylantrocamol LT3, were isolated along with six known ubiquinones from Antrodia cinnamomea (Polyporaceae) mycelium. The developed HPLC analysis methods successfully identified eight different ubiquinones, two benzenoids, and one maleic acid derivative from A. cinnamomea. The ubiquinones 1–8 exhibited potential and selective cytotoxic activity against three human cancer cell lines, with IC50 values ranging from 0.001 to 35.883 μM. We suggest that the different cytotoxicity levels were related to their chemical structures, especially the 4-hydroxycyclohex-2-enone ring and the presence of a free hydroxyl group in the side chain. The suppression by 4-acetylantrocamol LT3 stopped the cell cycle at the beginning of the G2-M phase thus making the cell cycle arrest at the sub-G1 phase as compared with control cells.Figures
http://www.lantyng.url.tw/cn/custom_70765.htmlSCI国际期刊 - Front. Pharmacol., 21 March 2016SCI国际期刊 - Front. Pharmacol., 21 March 2016Frontiers in Pharmacology., 21 March 2016 | https://doi.org/10.3389/fphar.2016.00067Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 CellsAntrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction. During chronic ER stress, misfolded proteins accumulate and initiate β-cell apoptosis. Moreover, β-cell dysfunction leads to defect in insulin secretion, which is the key process in the development and progression of T2DM. Therefore, the aim of the present study was to examine the effects of A. camphorata on insulin secretion and ER stress-induced apoptosis in a mouse β-cell line, MIN6, and their underlying mechanisms. We demonstrated that the ethanolic extract of A. camphorata increased glucose-induced insulin secretion dose-dependently through peroxisome proliferator-activated receptor-γ (PPAR-γ) pathway, and upregulated genes that were involved in insulin secretion, including PPAR-γ, glucose transporter-2 and glucokinase. Furthermore, A. camphorata slightly increased cell proliferation, as well as protected from ER stress-induced apoptosis in MIN6 cells. In conclusion, this study provided evidences that A. camphorata might have anti-diabetic effects and could be a novel drug for T2DM.ResultsAntrodia camphorata Enhanced Glucose-Induced Insulin Secretion through PPAR-γ PathwayFIGURE 1Antrodia camphorata Increased PPAR-γ, GLUT-2, and GLK Expressions in MIN6 CellsFIGURE 2Antrodia camphorata Protected from ER Stress-Induced Apoptosis in MIN6 CellsFIGURE 3FIGURE 4Antrodia camphorata Protected from Apoptosis through Downregulation of IRE1α Pathway in MIN6 CellsFIGURE 5
http://www.lantyng.url.tw/cn/custom_70762.htmlSCI国际期刊 - Fitoterapia. 2015, 102: 115-119.SCI国际期刊 - Fitoterapia. 2015, 102: 115-119.FitoterapiaVolume 102, April 2015, Pages 115-119Anti-cancer agents derived from solid-state fermented Antrodia camphorata myceliumAbstractThree new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata (Polyporaceae) mycelium. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analyses. These ubiquinones exhibited selective cytotoxicities against five human cancer cell lines (CT26, A549, HepG2, PC3 and DU-145) with IC50 values ranging from 0.01 to 1.79 μΜ.Graphical abstractThree new ubiquinone derivatives, antrocamol LT1, LT2 and LT3, were isolated from Antrodia camphorate mycelium and exhibited potential cytotoxicities against five human cancer cell lines.
http://www.lantyng.url.tw/cn/custom_67453.html全球13件专利认证全球13件专利认证美国专利3件证书号 US 9,622,990 B2证书号 US 9,474,775 B2证书号 US 9,249,117 B2
台湾专利7件证书号 I510237证书号 I569797证书号 I527583证书号 I543760证书号 I466677证书号 I583376证书号 I626053
大陆专利2件证书号 ZL2013 10204312 .X证书号 ZL2014 10080982 .X
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